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New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway
(Frontiers Research Foundation, 2015-03-25)
G protein coupled receptors (GPCRs) linked to stimulatory G (Gs) proteins (GsPCRs) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases, which differ considerably in their ...
Cyclic AMP efflux, via MRPs and A1 adenosine receptors, is critical for bovine sperm capacitation
(Oxford University Press, 2014-01)
Sperm capacitation has been largely associated with an increase in cAMP, although its relevance in the underlying mechanisms of this maturation process remains elusive. Increasing evidence shows that the extrusion of cAMP ...
Regulation of intracellular cyclic AMP in skeletal muscle cells involves the efflux of cyclic nucleotide to the extracellular compartment
(Nature Publishing Group, 2003-03-01)
1 This report analyses the intracellular and extracellular accumulation of cyclic AMP in primary rat skeletal muscle cultures,. after direct and receptor-dependent stimulation of adenylyl cyclase (AC).2 Isoprenaline, ...
MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux
(Wiley Blackwell Publishing, Inc, 2020-05)
Intracellular cAMP (i-cAMP) levels play an important role in acute myeloid leukemia (AML) cell proliferation and differentiation. Its levels are the result of cAMP production, degradation, and exclusion. We have previously ...
MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux
(Wiley Blackwell Publishing, Inc, 2020-04)
Intracellular cAMP (i-cAMP) levels play an important role in acute myeloid leukemia (AML) cell proliferation and differentiation. Its levels are the result of cAMP production, degradation, and exclusion. We have previously ...
MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation
(Company of Biologists, 2019-07)
Mammalian spermatozoa must undergo biochemical and structural changes to acquire the capacity for fertilization, in a process known as capacitation. Activation of PKA enzymes is essential for capacitation, and thus cAMP ...
Cyclic AMP efflux through MRP4 regulates actin dynamics signalling pathway and sperm motility in bovines
(Nature, 2020-09)
Previously we demonstrated that multidrug resistance-associated protein 4 transporter (MRP4) mediates cAMP efflux in bovine spermatozoa and that extracellular cAMP (ecAMP) triggers events associated to capacitation. Here, ...
Efflux pumps expression and its association with porin down-regulation and beta-lactamase production among Pseudomonas aeruginosa causing bloodstream infections in Brazil
(Biomed Central Ltd, 2010-08-12)
Background: Multi-drug efflux pumps have been increasingly recognized as a major component of resistance in P. aeruginosa. We have investigated the expression level of efflux systems among clinical isolates of P. aeruginosa, ...
Impacto do efluxo do AMP cíclico induzido pelos agonistas de adrenoceptores β2 e inibidores de fosfodiesterases no relaxamento do músculo liso das vias aéreas do rato
(Universidade Federal de São Paulo, 2022)
Os agonistas de adrenoceptores β2 e os inibidores de fosfodiesterases (PDE) são classes
de fármacos broncodilatadores que tem como mecanismo de ação comum a capacidade de
aumentar o 3’-5’-AMP cíclico (AMPc) intracelular. ...